Kolegij
Kolegij ___Receptorski mehanizmi u patogenezi upale i septičkog šoka______________je izborni predmet na _2___ godini Integriranog preddiplomskog i diplomskog sveučilišnog studija Medicina koji se održava u ljetnom___semestru, a sastoji se od _4__ sati predavanja, _17_ sati seminara i _4_ sati vježbi, ukupno 25__ sati (1,5 ECTS). Nastavni plan je slijedeći: 8.5. 2025. 10.00-13.00 P1 15.5. 2025. 10.00-13.00 V1 22.05. 2025 10.00-13.00 S1 29.05.2025. 10.00-13.00 S2 0506.2025. 10.00.13.00 S3 12.06. 2025 10.00-13.00 S4
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Cilj kolegija je _shvatiti mehanizme upale i septičkog šoka te upoznati receptore koji to posreduju.______________
1. Muhvić D. et al, The involvement of CD14 in the activation of human monocytes by peptidoglycan monomers, Mediators of inflammation, vol 10, 155-162, 2001. 2. Tak P.P. & Firestein G.S.,NF-kB:a key role in inflammatory diseases, J Clin Invest, vol 107, 7-11, 2001. 3. Heumann D. and Glauser M, Pathogenesis of sepsis, Sientific American,Science&Medicine 1994, 28- 37. 4. Glauser MP, Pathophysiologic basis of sepsis:Considerations for future strategies of intervention, Critical Care Medicine 2000;28:S4-S8. 5. Weideman B. et al., Soluble peptidoglycan-induced monokine production can be blocked by anti-CD14 monoclonal antibodies and by lipid A partial structures, Infection &Immunity, vol 62, 4709-4715, 1994. 6. Takeda K & Akira S, Toll-like receptors in inate immunity, International Immunology 17(1):1-14, 2005. 7.B.Weidemann et al.Specific binding of soluble peptidoglycan and muranyldipeptide to CD14 on human monocytes,Infection &Immunity, Mart 1997. 8.Parrillo JE,Pathogenetic mechanisms of septic shock,The new england journal of medicine,vol. 328, No20,1993 9.AG Tsitou et al ,Septic shock;current pathogenetic concepts from clinical perspective,Med SciMonit,2005;11(3);RA76-85 10.R.Dziarsky,Review:Recognition of bacterial peptidoglycan by the innate immune system,Cell.Mol.Life Sci.60 (2003) 1793-1804 |
- Patofiziologija udžbenik,Medicinska naklada,Zagreb 2018,osmo izdanje; 16.Poglavlje Upala,str.553-587.
Studenti su dužni pohađati sve oblike nastave!
Studenti koji su pohađali 70% nastave mogu izaći na završni ispit.
Kolegij se održava od 24.04 do 16.06. 2023.
Kolegij ___Receptorski mehanizmi u patogenezi upale i septičkog šoka______________je izborni predmet na _2___ godini Integriranog preddiplomskog i diplomskog sveučilišnog studija Medicina koji se održava u ljetnom___semestru, a sastoji se od _4__ sati predavanja, _17_ sati seminara i _4_ sati vježbi, ukupno 25__ sati (1,5 ECTS). Nastavni plan je slijedeći: 8.5. 2025. 10.00-13.00 P1 15.5. 2025. 10.00-13.00 V1 22.05. 2025 10.00-13.00 S1 29.05.2025. 10.00-13.00 S2 0506.2025. 10.00.13.00 S3 12.06. 2025 10.00-13.00 S4
|
Cilj kolegija je _shvatiti mehanizme upale i septičkog šoka te upoznati receptore koji to posreduju.______________
1. Muhvić D. et al, The involvement of CD14 in the activation of human monocytes by peptidoglycan monomers, Mediators of inflammation, vol 10, 155-162, 2001. 2. Tak P.P. & Firestein G.S.,NF-kB:a key role in inflammatory diseases, J Clin Invest, vol 107, 7-11, 2001. 3. Heumann D. and Glauser M, Pathogenesis of sepsis, Sientific American,Science&Medicine 1994, 28- 37. 4. Glauser MP, Pathophysiologic basis of sepsis:Considerations for future strategies of intervention, Critical Care Medicine 2000;28:S4-S8. 5. Weideman B. et al., Soluble peptidoglycan-induced monokine production can be blocked by anti-CD14 monoclonal antibodies and by lipid A partial structures, Infection &Immunity, vol 62, 4709-4715, 1994. 6. Takeda K & Akira S, Toll-like receptors in inate immunity, International Immunology 17(1):1-14, 2005. 7.B.Weidemann et al.Specific binding of soluble peptidoglycan and muranyldipeptide to CD14 on human monocytes,Infection &Immunity, Mart 1997. 8.Parrillo JE,Pathogenetic mechanisms of septic shock,The new england journal of medicine,vol. 328, No20,1993 9.AG Tsitou et al ,Septic shock;current pathogenetic concepts from clinical perspective,Med SciMonit,2005;11(3);RA76-85 10.R.Dziarsky,Review:Recognition of bacterial peptidoglycan by the innate immune system,Cell.Mol.Life Sci.60 (2003) 1793-1804 |
- Patofiziologija udžbenik,Medicinska naklada,Zagreb 2018,osmo izdanje; 16.Poglavlje Upala,str.553-587.
Studenti su dužni pohađati sve oblike nastave!
Studenti koji su pohađali 70% nastave mogu izaći na završni ispit.
Kolegij se održava od 24.04 do 16.06. 2023.
Kolegij ___Receptorski mehanizmi u patogenezi upale i septičkog šoka______________je izborni predmet na _2___ godini Integriranog preddiplomskog i diplomskog sveučilišnog studija Medicina koji se održava u ljetnom___semestru, a sastoji se od _4__ sati predavanja, _17_ sati seminara i _4_ sati vježbi, ukupno 25__ sati (1,5 ECTS). Nastavni plan je slijedeći: 8.5. 2025. 10.00-13.00 P1 15.5. 2025. 10.00-13.00 V1 22.05. 2025 10.00-13.00 S1 29.05.2025. 10.00-13.00 S2 0506.2025. 10.00.13.00 S3 12.06. 2025 10.00-13.00 S4
|
Cilj kolegija je _shvatiti mehanizme upale i septičkog šoka te upoznati receptore koji to posreduju.______________
1. Muhvić D. et al, The involvement of CD14 in the activation of human monocytes by peptidoglycan monomers, Mediators of inflammation, vol 10, 155-162, 2001. 2. Tak P.P. & Firestein G.S.,NF-kB:a key role in inflammatory diseases, J Clin Invest, vol 107, 7-11, 2001. 3. Heumann D. and Glauser M, Pathogenesis of sepsis, Sientific American,Science&Medicine 1994, 28- 37. 4. Glauser MP, Pathophysiologic basis of sepsis:Considerations for future strategies of intervention, Critical Care Medicine 2000;28:S4-S8. 5. Weideman B. et al., Soluble peptidoglycan-induced monokine production can be blocked by anti-CD14 monoclonal antibodies and by lipid A partial structures, Infection &Immunity, vol 62, 4709-4715, 1994. 6. Takeda K & Akira S, Toll-like receptors in inate immunity, International Immunology 17(1):1-14, 2005. 7.B.Weidemann et al.Specific binding of soluble peptidoglycan and muranyldipeptide to CD14 on human monocytes,Infection &Immunity, Mart 1997. 8.Parrillo JE,Pathogenetic mechanisms of septic shock,The new england journal of medicine,vol. 328, No20,1993 9.AG Tsitou et al ,Septic shock;current pathogenetic concepts from clinical perspective,Med SciMonit,2005;11(3);RA76-85 10.R.Dziarsky,Review:Recognition of bacterial peptidoglycan by the innate immune system,Cell.Mol.Life Sci.60 (2003) 1793-1804 |
- Patofiziologija udžbenik,Medicinska naklada,Zagreb 2018,osmo izdanje; 16.Poglavlje Upala,str.553-587.
Studenti su dužni pohađati sve oblike nastave!
Studenti koji su pohađali 70% nastave mogu izaći na završni ispit.
Kolegij se održava od 24.04 do 16.06. 2023.
Kolegij ___Receptorski mehanizmi u patogenezi upale i septičkog šoka______________je izborni predmet na _2___ godini Integriranog preddiplomskog i diplomskog sveučilišnog studija Medicina koji se održava u ljetnom___semestru, a sastoji se od _4__ sati predavanja, _17_ sati seminara i _4_ sati vježbi, ukupno 25__ sati (1,5 ECTS). Nastavni plan je slijedeći: 8.5. 2025. 10.00-13.00 P1 15.5. 2025. 10.00-13.00 V1 22.05. 2025 10.00-13.00 S1 29.05.2025. 10.00-13.00 S2 0506.2025. 10.00.13.00 S3 12.06. 2025 10.00-13.00 S4
|
Cilj kolegija je _shvatiti mehanizme upale i septičkog šoka te upoznati receptore koji to posreduju.______________
1. Muhvić D. et al, The involvement of CD14 in the activation of human monocytes by peptidoglycan monomers, Mediators of inflammation, vol 10, 155-162, 2001. 2. Tak P.P. & Firestein G.S.,NF-kB:a key role in inflammatory diseases, J Clin Invest, vol 107, 7-11, 2001. 3. Heumann D. and Glauser M, Pathogenesis of sepsis, Sientific American,Science&Medicine 1994, 28- 37. 4. Glauser MP, Pathophysiologic basis of sepsis:Considerations for future strategies of intervention, Critical Care Medicine 2000;28:S4-S8. 5. Weideman B. et al., Soluble peptidoglycan-induced monokine production can be blocked by anti-CD14 monoclonal antibodies and by lipid A partial structures, Infection &Immunity, vol 62, 4709-4715, 1994. 6. Takeda K & Akira S, Toll-like receptors in inate immunity, International Immunology 17(1):1-14, 2005. 7.B.Weidemann et al.Specific binding of soluble peptidoglycan and muranyldipeptide to CD14 on human monocytes,Infection &Immunity, Mart 1997. 8.Parrillo JE,Pathogenetic mechanisms of septic shock,The new england journal of medicine,vol. 328, No20,1993 9.AG Tsitou et al ,Septic shock;current pathogenetic concepts from clinical perspective,Med SciMonit,2005;11(3);RA76-85 10.R.Dziarsky,Review:Recognition of bacterial peptidoglycan by the innate immune system,Cell.Mol.Life Sci.60 (2003) 1793-1804 |
- Patofiziologija udžbenik,Medicinska naklada,Zagreb 2018,osmo izdanje; 16.Poglavlje Upala,str.553-587.
Studenti su dužni pohađati sve oblike nastave!
Studenti koji su pohađali 70% nastave mogu izaći na završni ispit.
Kolegij se održava od 24.04 do 16.06. 2023.
Ishodi učenja
Ishodi učenja:
Definirati osnovne pojmove i strukture: Studenti će biti u mogućnosti objasniti osnovne pojmove povezane s bakterijskim staničnim zidovima i prepoznati ključne sastavnice njihove kemijske strukture.
Identificirati ulogu u imunološkom odgovoru: Studenti će moći prepoznati kako određeni molekuli aktiviraju urođeni imunološki odgovor te opisati specifične mehanizme prepoznavanja patogenih molekula od strane imunosnog sustava.
Analizirati mehanizme signaliranja: Studenti će biti sposobni analizirati različite signalne puteve aktivirane pri kontaktu s bakterijskim staničnim komponentama i raspraviti njihov utjecaj na razvoj upale.
Procijeniti utjecaj na patogenezu: Studenti će procijeniti utjecaj bakterijskih molekula na razvoj raznih patoloških stanja uključujući upalu i septički šok, te objasniti njihovu ulogu u patogenezi bolesti.
Kritički vrednovati istraživanja: Studenti će razviti sposobnost kritičkog vrednovanja aktualnih znanstvenih istraživanja vezanih uz mehanizme djelovanja bakterijskih molekula u kontekstu patogeneze i moguće terapijske primjene.
Learning Outcomes:
Define basic concepts and structures: Students will be able to explain fundamental concepts related to bacterial cell walls and identify key components of their chemical structure.
Identify the role in immune response: Students will recognize how specific molecules activate the innate immune response and describe the mechanisms of pathogenic molecule recognition by the immune system.
Analyze signaling mechanisms: Students will be able to analyze different signaling pathways activated upon contact with bacterial cell components and discuss their impact on inflammation development.
Evaluate the impact on pathogenesis: Students will assess the impact of bacterial molecules on the development of various pathological conditions including inflammation and septic shock, and explain their role in disease pathogenesis.
Critically evaluate research: Students will develop the ability to critically evaluate current scientific research related to the mechanisms of bacterial molecule action in the context of pathogenesis and potential therapeutic applications.
Ishodi učenja
Proizvodnja monokina izazvana topivim peptidoglikanom može se blokirati anti CD14 monoklonskim protutijelima i parcijalnim strukturama lipida A