The aim of the course is to familiarize students with the pathological function of the immune system through the presentation of clinical cases. The emphasis is on explaining the pathophysiological mechanisms that lead to the disruption of normal immune processes, as well as on the possibilities of therapeutic actions on the immune reaction. The tasks of the class are to enable the student to connect basic knowledge in immunology and the pathophysiology of the immune system with nosological entities found in clinical medicine. The course includes the following entities: X-linked agammaglobulinemia, Congenital asplenia, MHC class I deficiency, X-linked severe combined immunodeficiency, Toxic shock syndrome, Hereditary angioneurotic edema, Graft-versus-host reaction, AIDS, Myasthenia gravis, Allergic asthma, Multiple sclerosis, Rheumatic fever