Kolegij
Studiji
Medical Studies in EnglishStudijska godina
6ISVU ID
239418ECTS
3
The Clinical Pharmacology course is a compulsory course at the sixth year of the Integrated Undergraduate and Graduate University Study of Medicine and consists of 10 hours of lectures and 45 hours of seminars, a total of 55 hours (3 ECTS). The course is conducted in the premises of the Faculty of Medicine, Clinical Hospital Center and the building of the Faculty of Health Studies. The aim of the course is to enable students to acquire knowledge of clinical pharmacology principles that are necessary for the implementation of rational pharmacotherapy. The student should acquire knowledge about the latest achievements in the field of medicines and the conditions prevailing in the health care system, which are important for the rational use of medicines (eg. lists of medicines, financial limits for medicines, patient’s participation for medicines). The content of the course is as follows: A. General principles of clinical pharmacology - drug discovery and development, pharmacoeconomics, pharmacoepidemiology, drug side effects and interactions, principles of clinical drug use in certain groups of patients, pharmacogenomics (individualization of therapy) and basic principles of toxicology. B. Rational pharmacotherapy of selected clinical entities - this part of the course will cover the use of drugs in the treatment of the most common diseases and conditions, characterized with high utilisation and a significant share of financial consumption (eg. antimicrobial drugs, antihypertensives, hypolipemics, benzodiazepines, drugs for diabetes, pain treatment, supportive treatment of malignant diseases, etc.). Teaching: Classes are held in the form of lectures and seminars. Estimated duration of classes is up to a total of 2 weeks. During the seminar, the teacher discusses with students the specific principles of clinical pharmacology and the treatment of special clinical entities. During the classes there will be a written test and a written final exam. By completing all teaching activities and passing the above tests, the student acquires 3 ECTS credits. Up to 40% of classes can be held online and students will be informed about it. If a student justifiably or unjustifiably misses more than 30% of classes in which mandatory attendance monitoring is performed (seminars), he / she cannot continue the course and loses the possibility for the final exam. He thus collected 0 ECTS credits and was graded F.
Katzung BG, Masters SB, Trevor AJ. Basic and Clinical Pharmacology. McGraw Hill / Medical
Francetić I, Vitezić D. Klinička farmakologija. Medicinska naklada, Zagreb 2014. Laurence DR, Bennett PN, Brown MJ. Clinical Pharmacology. Churchill Livingstone
Students are required for regular attendance and active participation in all forms of teaching.
ECTS credit grading system:
Student assessment is carried out according to the current Regulations on Studies of the University of
Rijeka.
Student work will be evaluated and graded during classes and at the final exam. Out of a total of 100
points, during the classes the student can achieve 70 points, and at the final exam 30 points.
Student assessment is performed using ECTS (A-E) and number system (1-5). Grading in the ECTS system
is performed by absolute distribution.
Out of a total of 100 points, during the classes the student can achieve 70 points, and at the final exam 30
points. During classes, the result achieved by solving the compulsory test is evaluated (up to a maximum
of 70 points).
The final exam can be taken by those students who have achieved at least 50% of the maximum possible
points during the classes.
Students who have achieved less than 35 points during classes are not eligible to take the final exam (final
grade F). The final exam is written.
I. During classes, the following is evaluated (maximum up to 70 points):
Mandatory test (up to 70 points)
The written test consists of 70 questions, and carries 70 points (each correctly solved question carries one
grade).
The material of the compulsory test contains questions that cover topics from general and special clinical
pharmacology covered by lectures and seminars.
II. Final exam (total 30 points):
Who can take the final exam:
Students who have achieved more than 50% of points during the course must take the final written
exam where they can achieve a maximum of 30 points.
Who cannot take the final exam:
Students who have achieved less than 35 points during the class do not have the right to take the final
exam (enroll the course the next year).
The final exam is a written exam. Carries 30 points (range 15-30).
The written test consists of 50 questions (the criterion for obtaining grades is 50% of correctly solved
questions), and it consists of questions that cover the entire content of the course.
Correct answers obtained on the written test are converted into points as follows:
Correct answers Points Points
0-25 0
26 15
27 16
28 17
29 18
30 19
31 20
32 21
33,34 22
35,36 23
37,38 24
39,40 25
41,42 26
43,44 27
45,46 28
47,48 29
49,50 30
To pass the final exam and for the final grade (including adding up the previously obtained points during
classes) the student must have a positive grade on the final exam and achieve a minimum of 15 points
(50%).
The final grade of the exam is formed on the basis of the achieved results, and in the following way:
90-100% (points) A (excellent, 5)
75-89,9% ( points ) B (very good, 4)
60-74,9% ( points ) C ( good, 3)
50-59,9% ( points ) D ( pass, 2)
0-49,9% ( points ) F ( fail, 1)
Teaching content and all information related to the course as well as exam dates can be found on the web pages.
Ishodi učenja
Explain and know the principles how the medicines are choosen and prescribed for the patient. Explain curative, symptomatic and prophylactic treatment based on examples.
Ishodi učenja
Know the basic principles of clinical pharmacology. Know and explain the principles of clinical drug trials and how they are performed in practice.
Ishodi učenja
Explain the specifics of pregnancy with regard to drug therapy. Know the reasons how the pregnancy could influence the drug therapy. Know how to conduct clinical-pharmacological counseling in pregnant women.
Ishodi učenja
Be able to explain the side effects of medications and the types of side effects depending on the cause. Explain the cause-and-effect relationship between drug administration and side effects. Understand the mechanisms of drug-drug interactions. Explain individual interactions concerning their mechanism.
Ishodi učenja
Explain the meaning of the regulatory body in the field of medicines, i.e. the Croatian Agency for Medicinal Products and Medical Devices (HALMED). Know how to get information from HALMED. Explain the importance and position of HALMED in national drug policy.
Ishodi učenja
Explain and know what generic drugs are and how they must meet regulatory criteria. Explain why it is adopted and what are the characteristics of national drug policy (generic drugs in national policy).
Ishodi učenja
Explain the specifics of special populations regarding the drug therapy. To know the reasons for individualization of treatment, i.e. adequate drug dosing. Know how to conduct clinical-pharmacological counseling on drug therapy in pregnant women. Explain side effects and interactions in the elderly and in the pediatric population.
Ishodi učenja
Explain and know the basic principles of pharmacoeconomics that include the use of the most common analysis and techniques. Know and explain costs-effectiveness analysis (and benefits) and the way in which the value of the drug is estimated.
Ishodi učenja
Explain pharmacogenetics (the genetic basis of interindividual variability) and its significance to the pharmacotherapeutic response. Know the influence of gene polymorphism on pharmacokinetic parameters and drug pharmacodynamics.
Ishodi učenja
Explain the principles of toxicology and the effects of toxic substances in the body. Know the routes of entry of toxic substances into the body, duration of exposure and the response to exposure to toxic substances. Explain toxicity testing and risk assessment tests.
Ishodi učenja
Explain the principles of treatment of bronchial asthma in accordance with recent GINA guidelines. Be able to explain the mechanisms of action and use of certain groups of drugs used in the treatment of asthma. Explain the treatment of asthma exacerbations.
Ishodi učenja
Be able to explain and recognize certain types of pain. Know the treatment of pain by type (treatment of acute pain, treatment of chronic pain, treatment of malignant pain). Know the most important principles in the treatment of malignant pain and the principles of analgesic use in accordance with WHO principles. Know the guidelines for the application of NSAIDs and their characteristics.
Ishodi učenja
Know the guidelines for supportive care in patients with malignancies. To be able to treat anemia, nausea and vomiting caused by chemotherapy and anorexia-cachexia syndrome. Explain the groups of drugs used in these entities.
Ishodi učenja
Be able to use guidelines in the use of antidepressants and the selection of antidepressants. Know the principles of treatment of schizophrenia and other psychotic disorders.
Ishodi učenja
Know drugs with anxiolytic effect. Explain the general principles of anxiolytic treatment in the most common nosological entities.
Ishodi učenja
Know the groups of antimicrobial drugs and explain the therapeutic principles according to the recommendations in cases of prophylactic use. Be able to make a choice of antimicrobial drug in empirical therapy depending on the site of infection. Explain the targeted use of antimicrobials and the problem of resistance.
Ishodi učenja
Explain the principles of treatment of the most common cardiac diseases in accordance with recent guidelines. Be able to explain the mechanisms of action and use of certain groups of drugs in these clinical entities (drugs in acute coronary syndrome without ST-elevation, drugs in acute coronary syndrome with persistent ST-elevation, antihypertensives, hypolipemics, drugs in the treatment of chronic heart failure). Explain the guidelines for the treatment of anaphylaxis and know the groups of drugs used according to severity and the mechanism of action in this condition.
Ishodi učenja
Be able to use guidelines for the peptic ulcer therapy. Know the recommendations for the treatment of peptic ulcer positive for H. pylori (eradication therapies), peptic ulcer caused by NSAIDs, H. pylori negative ulcer. Explain the principles of constipation treatment.
Ishodi učenja
Know how to choose a rational therapy for the mentioned conditions. Explain the guidelines in the treatment of type I and II diabetes and obesity. Know and explain why certain drugs are used in certain lines of treatment.
Ishodi učenja
Know how to define biological drugs. Explain the place of biological drugs in the treatment of certain medical entities.
Ishodi učenja
Explain and know the principles how the medicines are choosen and prescribed for the patient. Explain curative, symptomatic and prophylactic treatment based on examples.
Ishodi učenja
Know the basic principles of clinical pharmacology. Know and explain the principles of clinical drug trials and how they are performed in practice.
Ishodi učenja
Explain the specifics of pregnancy with regard to drug therapy. Know the reasons how the pregnancy could influence the drug therapy. Know how to conduct clinical-pharmacological counseling in pregnant women.
Ishodi učenja
Be able to explain the side effects of medications and the types of side effects depending on the cause. Explain the cause-and-effect relationship between drug administration and side effects. Understand the mechanisms of drug-drug interactions. Explain individual interactions concerning their mechanism.
Ishodi učenja
Explain the meaning of the regulatory body in the field of medicines, i.e. the Croatian Agency for Medicinal Products and Medical Devices (HALMED). Know how to get information from HALMED. Explain the importance and position of HALMED in national drug policy.
Ishodi učenja
Explain and know what generic drugs are and how they must meet regulatory criteria. Explain why it is adopted and what are the characteristics of national drug policy (generic drugs in national policy).
Ishodi učenja
Explain the specifics of special populations regarding the drug therapy. To know the reasons for individualization of treatment, i.e. adequate drug dosing. Know how to conduct clinical-pharmacological counseling on drug therapy in pregnant women. Explain side effects and interactions in the elderly and in the pediatric population.
Ishodi učenja
Explain and know the basic principles of pharmacoeconomics that include the use of the most common analysis and techniques. Know and explain costs-effectiveness analysis (and benefits) and the way in which the value of the drug is estimated.
Ishodi učenja
Explain pharmacogenetics (the genetic basis of interindividual variability) and its significance to the pharmacotherapeutic response. Know the influence of gene polymorphism on pharmacokinetic parameters and drug pharmacodynamics.
Ishodi učenja
Explain the principles of toxicology and the effects of toxic substances in the body. Know the routes of entry of toxic substances into the body, duration of exposure and the response to exposure to toxic substances. Explain toxicity testing and risk assessment tests.
Ishodi učenja
Explain the principles of treatment of bronchial asthma in accordance with recent GINA guidelines. Be able to explain the mechanisms of action and use of certain groups of drugs used in the treatment of asthma. Explain the treatment of asthma exacerbations.
Ishodi učenja
Be able to explain and recognize certain types of pain. Know the treatment of pain by type (treatment of acute pain, treatment of chronic pain, treatment of malignant pain). Know the most important principles in the treatment of malignant pain and the principles of analgesic use in accordance with WHO principles. Know the guidelines for the application of NSAIDs and their characteristics.
Ishodi učenja
Know the guidelines for supportive care in patients with malignancies. To be able to treat anemia, nausea and vomiting caused by chemotherapy and anorexia-cachexia syndrome. Explain the groups of drugs used in these entities.
Ishodi učenja
Be able to use guidelines in the use of antidepressants and the selection of antidepressants. Know the principles of treatment of schizophrenia and other psychotic disorders.
Ishodi učenja
Know drugs with anxiolytic effect. Explain the general principles of anxiolytic treatment in the most common nosological entities.
Ishodi učenja
Know the groups of antimicrobial drugs and explain the therapeutic principles according to the recommendations in cases of prophylactic use. Be able to make a choice of antimicrobial drug in empirical therapy depending on the site of infection. Explain the targeted use of antimicrobials and the problem of resistance.
Ishodi učenja
Explain the principles of treatment of the most common cardiac diseases in accordance with recent guidelines. Be able to explain the mechanisms of action and use of certain groups of drugs in these clinical entities (drugs in acute coronary syndrome without ST-elevation, drugs in acute coronary syndrome with persistent ST-elevation, antihypertensives, hypolipemics, drugs in the treatment of chronic heart failure). Explain the guidelines for the treatment of anaphylaxis and know the groups of drugs used according to severity and the mechanism of action in this condition.
Ishodi učenja
Be able to use guidelines for the peptic ulcer therapy. Know the recommendations for the treatment of peptic ulcer positive for H. pylori (eradication therapies), peptic ulcer caused by NSAIDs, H. pylori negative ulcer. Explain the principles of constipation treatment.
Ishodi učenja
Know how to choose a rational therapy for the mentioned conditions. Explain the guidelines in the treatment of type I and II diabetes and obesity. Know and explain why certain drugs are used in certain lines of treatment.
Ishodi učenja
Know how to define biological drugs. Explain the place of biological drugs in the treatment of certain medical entities.